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Defined Bioscience

Immuno-oncology

Immuno-oncology and Immunotherapy Using Human Induced Pluripotent STEM Cells (iPSCs)

Human induced pluripotent stem cells (iPSCs) are emerging as a critical tool in the development of next-generation immunotherapies. They enable the scalable and renewable generation of engineered immune cells, including T cells, NK cells, and macrophages, with potential for allogeneic, off-the-shelf applications. iPSCs also support disease modeling and target validation in immuno-oncology research.

iPSCs provide a renewable source for producing genetically modified immune cells tailored for cancer immunotherapy. Unlike primary immune cells, iPSCs can be expanded indefinitely and genetically edited with high efficiency. This capability enables the creation of homogeneous populations of CAR-T cells, CAR-NK cells, and other engineered immune effectors for both research and therapeutic applications.

Generating functional immune cells from iPSCs requires complex differentiation protocols, and ensuring the consistency and cytotoxic potency of these cells remains challenging. Additionally, existing immune cell sources are limited in scalability and standardization, which hinders broad application in both personalized and off-the-shelf cell therapies.

Defined Bioscience provides high-quality, defined, animal-free media that streamline the production of iPSC-derived immune cells. HiDef-B8 supports robust pluripotent stem cell expansion, while Ready-CEPT improves viability and clonal outgrowth. HiDef-S8 (currently available in early access) is designed for high-density, suspension-based expansion workflows—ideal for scaling production of immune precursors. These products offer consistency, reduce variability, and support scalable workflows essential for immuno-oncology applications.

Defined Bioscience
HiDef-B8 400X Supplement - Defined Bioscience

HiDef® B8 Stem Cell Growth Medium

From $150.00
From $150.00 $150.00
Defined Bioscience
Ready-CEPT™ Cell Viability Enhancer - Defined Bioscience

Ready-CEPT™ Cell Viability Enhancer

From $150.00
From $150.00
Defined Bioscience
HiDef® PBS/EDTA Cell Dissociation Reagent - Defined Bioscience

HiDef® PBS/EDTA Cell Dissociation Reagent

From $18.00
From $18.00
Defined Bioscience
HiDef® N-2 Neural Medium Supplement - Defined Bioscience

HiDef® N-2 Neural Medium Supplement

From $100.00
From $100.00
Defined Bioscience
HiDef-ITS Cell Culture Supplement - Defined Bioscience

HiDef® ITS Cell Culture Supplement

From $70.00
From $70.00

Key Defined Bioscience Products for Immuno-oncology

HiDef-B8: Complete, serum-free, defined media ideal for maintaining pluripotency and efficient differentiation.

Ready-CEPT: Optimized supplement promoting enhanced viability and functional capability in various cell types.

HiDef PBS/EDTA: Defined phosphate-buffered saline solution for gentle cell dissociation.

HiDef N-2: Defined neural supplement to support robust neural differentiation.

HiDef-ITS: Defined insulin-transferrin-selenium supplement to enhance proliferation efficiency and cell viability.

Application Notes

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High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

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Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

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Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

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Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

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Contact and Collaboration Opportunities

Defined Bioscience actively engages with the scientific community to support disease modeling research. We encourage researchers to reach out to our technical experts for collaboration opportunities, protocol optimization, and troubleshooting assistance.

info@definedbioscience.com

By leveraging Defined Bioscience products, researchers can accelerate their disease modeling studies, enhance experimental reliability, and advance therapeutic discoveries.

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