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Defined Bioscience

Disease Modeling

Disease Modeling Using Human Induced Pluripotent STEM Cells (iPSCs)

Disease modeling with human induced pluripotent stem cells (iPSCs) allows scientists to study complex diseases in a controlled laboratory setting by replicating patient-specific genetic backgrounds. This approach has significantly advanced our understanding of numerous diseases, including Alzheimer's, Parkinson's, cardiovascular disorders, metabolic conditions, and rare genetic syndromes.

iPSCs offer a unique advantage by capturing individual genetic profiles, enabling precise investigation of disease mechanisms. They are ethically sourced, scalable, and highly versatile, allowing differentiation into specific cell types such as neurons, cardiomyocytes, hepatocytes, and pancreatic beta cells. Using patient-derived cells provides insights into personalized disease pathology, potentially revolutionizing therapeutic discovery and precision medicine.

Despite their potential, traditional iPSC disease modeling faces challenges such as variability in cell culture conditions, inconsistency in differentiation protocols, and high costs associated with media formulations. These hurdles often limit reproducibility and scalability, hampering broader adoption in disease modeling applications.

Defined Bioscience provides advanced, defined, serum-free, and cost-effective solutions specifically tailored for iPSC culture and differentiation. Our flagship media product, HiDef-B8 and our viability supplement, Ready-CEPT, offer consistent and reproducible conditions, significantly reducing variability and costs compared to traditional media. These optimized formulations support robust growth and efficient differentiation, ensuring reproducible and reliable disease modeling.

Defined Bioscience
HiDef-B8 400X Supplement - Defined Bioscience

HiDef® B8 Stem Cell Growth Medium

From $150.00
From $150.00 $150.00
Defined Bioscience
Ready-CEPT™ Cell Viability Enhancer - Defined Bioscience

Ready-CEPT™ Cell Viability Enhancer

From $150.00
From $150.00
Defined Bioscience
HiDef® PBS/EDTA Cell Dissociation Reagent - Defined Bioscience

HiDef® PBS/EDTA Cell Dissociation Reagent

From $18.00
From $18.00
Defined Bioscience
HiDef® N-2 Neural Medium Supplement - Defined Bioscience

HiDef® N-2 Neural Medium Supplement

From $100.00
From $100.00
Defined Bioscience
HiDef-ITS Cell Culture Supplement - Defined Bioscience

HiDef® ITS Cell Culture Supplement

From $70.00
From $70.00

Key Defined Bioscience Products for Disease Modeling

HiDef-B8: Complete, serum-free, defined media ideal for maintaining pluripotency and efficient differentiation.

Ready-CEPT: Optimized supplement promoting enhanced viability and function in a wide range of cell types.

HiDef PBS/EDTA: Defined phosphate-buffered saline solution for gentle cell dissociation.

HiDef-N2: Defined neural supplement to support robust neural differentiation.

HiDef-ITS: Defined insulin-transferrin-selenium supplement to enhance proliferation efficiency and cell viability.

Application Notes

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High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

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Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

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Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

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Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

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Contact and Collaboration Opportunities

Defined Bioscience actively engages with the scientific community to support disease modeling research. We encourage researchers to reach out to our technical experts for collaboration opportunities, protocol optimization, and troubleshooting assistance.

info@definedbioscience.com

By leveraging Defined Bioscience products, researchers can accelerate their disease modeling studies, enhance experimental reliability, and advance therapeutic discoveries.

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Get in Touch

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