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Defined Bioscience

Drug Discovery and Toxicology

IPSC-Based Models Transforming How Drugs are Tested for Safety and Effectiveness.

Human induced pluripotent stem cells (iPSCs) have revolutionized drug discovery and toxicology studies by enabling the development of human-relevant, patient-specific cell models. These advanced models significantly enhance the predictive accuracy of drug efficacy and safety assessments compared to traditional animal models and immortalized cell lines.

iPSCs can differentiate into virtually any human cell type, including hepatocytes, cardiomyocytes, and neuronal cells, providing biologically relevant systems for evaluating therapeutic candidates. Their use in drug discovery reduces reliance on animal models, lowers costs, improves scalability, and increases the predictive power of preclinical studies, facilitating a smoother transition to clinical trials.

Traditional methods for drug screening and toxicity testing often rely on animal models or immortalized cell lines, which lack predictive accuracy and physiological relevance to human biology. Variability in iPSC culture conditions and differentiation protocols can also hinder reproducibility, while high costs associated with specialized media and cell culture reagents present additional barriers.

Defined Bioscience offers advanced, serum-free, defined media formulations tailored to support consistent and reproducible iPSC maintenance and differentiation. Our HiDef-B8 medium and Ready-CEPT supplement significantly improve the efficiency and reliability of generating functional cell models, reducing variability, and enabling robust, scalable drug screening and toxicological assessments.

Defined Bioscience
HiDef-B8 400X Supplement - Defined Bioscience

HiDef® B8 Stem Cell Growth Medium

From $150.00
From $150.00 $150.00
Defined Bioscience
Ready-CEPT™ Cell Viability Enhancer - Defined Bioscience

Ready-CEPT™ Cell Viability Enhancer

From $150.00
From $150.00
Defined Bioscience
HiDef® PBS/EDTA Cell Dissociation Reagent - Defined Bioscience

HiDef® PBS/EDTA Cell Dissociation Reagent

From $18.00
From $18.00
Defined Bioscience
HiDef® N-2 Neural Medium Supplement - Defined Bioscience

HiDef® N-2 Neural Medium Supplement

From $100.00
From $100.00
Defined Bioscience
HiDef-ITS Cell Culture Supplement - Defined Bioscience

HiDef® ITS Cell Culture Supplement

From $70.00
From $70.00

Key Defined Bioscience Products for Drug Discovery and Toxicology

HiDef-B8: Complete, serum-free, defined media ideal for maintaining pluripotency and efficient differentiation.

Ready-CEPT: Optimized supplement promoting enhanced viability and functional capability in various cell types.

HiDef PBS/EDTA: Defined phosphate-buffered saline solution for gentle cell dissociation.

HiDef N-2: Defined neural supplement to support robust neural differentiation.

HiDef-ITS: Defined insulin-transferrin-selenium supplement to enhance proliferation efficiency and cell viability.

Application Notes

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High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

High-density pluripotent stem cell expansion in a single-use bioreactor using HiDef S8

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Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

Optimized Expansion, Cryopreservation, and Recovery of Clinical Grade, PluriBank iPSCs Using a Defined Reagent System Kit

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Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

Comparative Analysis of 2D and 3D Differentiation Approaches for iPSC-Derived Neural Cells

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Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

Isolating Induced Pluripotent Stem Cells by Using the WOLF G2 to Sort Stemness-Related Surface Markers

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Contact and Collaboration Opportunities

Defined Bioscience actively engages with the scientific community to support disease modeling research. We encourage researchers to reach out to our technical experts for collaboration opportunities, protocol optimization, and troubleshooting assistance.

info@definedbioscience.com

By leveraging Defined Bioscience products, researchers can accelerate their disease modeling studies, enhance experimental reliability, and advance therapeutic discoveries.

 Contact

Customer Service

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Call Us

+1 929-333-4633

Get in Touch

techsupport@definedbioscience.com
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